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Polynucleotide Treatments at Skin Medical

Explore the benefits of a polynucleotide treatment at Skin Medical for a healthy skin boost.

What is a polynucleotide treatment? 

Injectable polynucleotide treatments are a highly effective way to rejuvenate your skin by targeting fine lines, dullness, and sagging. Using a naturally derived substance from DNA fragments, this treatment enhances your skin’s ability to repair itself, improving elasticity, texture, and hydration.

Polynucleotides treatments are great for improving the quality of your skin and giving an instant, refreshed look. As we age, the body’s production of collagen declines, leading to the formation of wrinkles, fine lines, and sagging skin. By stimulating fibroblasts within the skin and enhancing collagen production, polynucleotides help restore firmness to the skin, resulting in a more youthful appearance. If you are looking for a more long-term approach to collagen restoration, you should be considering a collagen stimulator such as Lanluma, Ellanse or Sculptra which work in the deeper layers of the skin. 

Why Choose Polynucleotide Treatments?

Unlike other injectable treatments, polynucleotides don’t just mask the signs of ageing they actually help your skin heal itself from within.

By stimulating your body’s natural regenerative processes, this treatment builds collagen, improves elasticity, and deeply hydrates, giving you gradual but long-lasting results.

  • Natural-looking results: You’ll look refreshed, not “done.”
  • Minimal downtime: Return to your normal routine almost immediately.
  • Tailored for you: Every treatment is customised to your specific needs and goals.
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Why Choose Skin Medical for Polynucleotide Treatments?

At Skin Medical, we pride ourselves on delivering natural-looking results that enhance your beauty rather than altering it. Dr Sabika Karim and Dr Saif are trusted experts in aesthetic medicine, known for their patient-first approach and bespoke treatment plans.

From the initial consultation to post-treatment care, we’re here to ensure your journey is smooth, safe, and successful. If you’re ready to transform your skin, book your consultation today and let us help you achieve the glowing, youthful complexion you deserve.

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Where can we treat with Polynucleotides? 

As well as for facial rejuvenation, polynucleotides are effective for hair restoration, body contouring, and scar treatments. 

In hair restoration, polynucleotides promote the growth and breadth of dermal papilla cells and improve blood circulation to the scalp, resulting in thicker, healthier hair. For body contouring, polynucleotides help to remodel tissues, leading to smoother, more sculpted contours. 

In scar treatments, polynucleotides regulate fibroblast activity and collagen synthesis, helping to soften and refine the appearance of scars.

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Polynucleotide Frequently asked questions

Still have questions? Contact our team who will be happy to answer any queries or concerns.

What exactly are polynucleotides?

Polynucleotides are long chains of nucleotides, the building blocks of DNA and RNA. These chains possess unique properties that interact with cellular receptors, modulating essential signalling pathways and offering benefits in skin rejuvenation and other aesthetic applications.

What are polynucleotides made from?

Polynucleotides can be derived from various sources, including salmon DNA, or synthesised in a laboratory. Regardless of their origin, they retain the structural and functional properties necessary for their therapeutic effects.

Do polynucleotides injections work?

Polynucleotide injections have shown efficacy in promoting collagen synthesis, tissue repair, and overall skin health. Results may vary among individuals, but many patients experience noticeable improvements in skin quality and appearance over time with consistent treatment.

How much do polynucleotides cost?

The cost of polynucleotide therapy can vary depending on factors such as treatment area, the extent of the procedure, and geographic location. Our Polynucleotide treatments start from £300. 

Can you have polynucleotides if you are allergic to fish?

Individuals with fish allergies should exercise caution when considering polynucleotide therapy, particularly if derived from salmon DNA. Alternative sources or synthesised polynucleotides may be preferable for those with known allergies.

At what age should I get polynucleotides injections?

There is no specific age requirement for polynucleotide therapy, as suitability depends on individual skin concerns and treatment goals. Consultation with a qualified practitioner can help determine the most appropriate timing for treatment.

How long do polynucleotides take to work?

Polynucleotide therapy yields gradual results, with timelines varying based on individual response and the treated area. While some patients may notice improvements within a few weeks, optimal outcomes typically develop over time with consistent treatment.

Where can I get polynucleotides?

Polynucleotide therapy is offered by qualified healthcare providers, including dermatologists, plastic surgeons, and aesthetic practitioners. Patients should seek treatment from reputable professionals experienced in administering injectable therapies.

Does polynucleotide treatment hurt?

Polynucleotide treatment is not usually painful, with minimal discomfort reported by most patients. Topical anaesthetics or numbing agents may be applied to enhance comfort during the procedure.

Polynucleotide Treatment Aftercare at Skin Medical

Following polynucleotide treatment at Skin Medical, most patients experience minimal downtime and can return to their normal routine almost immediately. Some mild redness, swelling and small bumps at the injection sites is entirely normal and typically settles within 24 to 48 hours. Results develop gradually as the treatment works at a cellular level to stimulate fibroblast activity, build collagen and deeply hydrate the skin, with visible improvements in tone, texture and radiance becoming apparent over the following weeks. A course of treatments is recommended for optimal results.

Polynucleotide Treatment Aftercare Summary

Polynucleotides are naturally derived, purified DNA fragments that actively stimulate the skin’s own regenerative processes from within. By encouraging collagen and elastin production and improving skin hydration, they deliver gradual, natural-looking improvements in skin quality without masking the signs of ageing. At Skin Medical, polynucleotide treatments are used for facial rejuvenation, hair restoration, body contouring and scar treatment, with every treatment plan personalised to your skin concerns and goals by Dr Sabika Karim and Dr Saif Abbas Chatoo.

Polynucleotide Pre-Treatment Guidance

To prepare for your polynucleotide appointment at Skin Medical:

  • Arrive with clean skin, free from make-up or skincare products in the treatment area
  • Eat before your appointment to ensure comfort during treatment
  • Stay well hydrated in the days leading up to your visit
  • Avoid blood-thinning medications such as aspirin or ibuprofen where possible in the days before treatment, unless prescribed by your doctor
  • Avoid alcohol for 24 hours before your appointment to minimise the risk of bruising
  • Inform your practitioner of any active skin conditions, allergies or recent treatments in the treatment area at your consultation
  • A consultation is compulsory before all polynucleotide treatments at Skin Medical

During your appointment:

  • Clinical photographs and consent will be completed before treatment begins
  • The treatment area will be cleansed thoroughly
  • Treatment time is typically 30 to 45 minutes

What to Expect Immediately After Polynucleotides

Polynucleotide treatment is a well-tolerated procedure with minimal downtime for most patients.

You may experience:

  • Mild redness and swelling at and around the injection sites
  • Small raised bumps where the product has been placed, which settle naturally over 24 to 48 hours
  • Light bruising, particularly in more delicate areas such as under the eyes
  • Temporary tenderness or sensitivity to touch

These effects are entirely normal and are a sign that the treatment has been administered correctly. Because polynucleotides work gradually by stimulating your skin’s own repair processes, there is no sudden or dramatic change immediately after treatment.

Polynucleotide Post-Treatment Care

To support your skin’s recovery and help the treatment work as effectively as possible, we recommend the following after your appointment.

  • Keep the skin clean and avoid touching or rubbing the treated area for the first 24 hours
  • Apply a gentle, fragrance-free moisturiser to keep the skin comfortable and hydrated
  • Use a broad-spectrum SPF 30 or above daily, as UV exposure can undermine the regenerative process and compromise your results
  • Avoid make-up for at least 12 hours following treatment, or until any redness has settled
  • Avoid alcohol for 24 hours post-treatment to reduce bruising and swelling
  • Avoid retinoids, exfoliating acids and active skincare for at least 48 hours after treatment
  • Avoid intense exercise, saunas, steam rooms and hot baths for 24 to 48 hours
  • Avoid prolonged sun exposure and sunbeds in the weeks following treatment

If you experience significant or worsening swelling, any signs of infection or unusual discomfort beyond 48 hours, please contact our team promptly.

When Will I See Results from Polynucleotides?

Polynucleotides work by stimulating the skin’s own regenerative processes, which means improvements develop gradually and authentically over time.

  • Initial improvements in hydration and skin quality may be noticeable within the first one to two weeks
  • More visible improvements in tone, texture, firmness and radiance typically become apparent over two to four weeks
  • Results continue to develop over the following months as collagen and elastin production increases
  • A course of treatments is recommended for optimal correction, with sessions typically spaced four to six weeks apart

Because polynucleotides regenerate rather than fill, the outcome is a gradual and authentic improvement that looks entirely natural and continues to build with each session.

Who May Not Be Suitable for Polynucleotide Treatment?

Polynucleotide treatment may not be suitable if you have:

  • Active skin infections, open wounds or compromised skin in the treatment area
  • A known allergy to fish or fish-derived products, as polynucleotides are sourced from purified salmon DNA
  • Certain autoimmune conditions or skin disorders affecting the treatment area
  • Are pregnant or breastfeeding

A full consultation will be carried out before treatment to confirm suitability and ensure the approach is personalised to your skin concerns and long-term goals.

When to Contact Skin Medical

Polynucleotide treatment is a safe and well-established regenerative procedure when performed by an experienced medical team. However, please contact Skin Medical if you experience:

  • Persistent or worsening swelling beyond 48 hours
  • Signs of infection such as increasing redness, heat or discharge
  • An allergic reaction or unusual skin response following treatment
  • Any unexpected changes in the treated area

We are here to support you following your treatment and to answer any questions as your skin continues to renew and regenerate.

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A special shoutout to our amazing patient Kerryn — we are so proud of you for running the marathon and raising money for @brainresearchuk 💙 Your determination and dedication are inspiring.

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#SkinMedical #aestheticmedicine #patientfeedbackA subtle refresh for the under-eye area. 

Tear trough treatment can help reduce the appearance of tiredness, restoring a brighter, more rested look while keeping results natural.

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Good luck to everyone taking on the London Marathon tomorrow! 🏃‍♀️🏃‍♂️🇬🇧

A special shoutout to our amazing patient Kerryn — we are so proud of you for running the marathon and raising money for @brainresearchuk 💙 Your determination and dedication are inspiring.

If you’d like to support Kerryn and Team Neurodashers, you can sponsor here:
https://www.justgiving.com/page/team-neurodashers?utm_medium=FR&utm_source=CL

Wishing every runner the best of luck — enjoy every mile, soak up the atmosphere, and know we’ll be cheering you on all the way to the finish line! 🙌

#LondonMarathon #LondonMarathon2026 #GoodLuckRunners #BrainResearchUK #TeamNeurodashers #Fundraising #MarathonDay #RunningCommunity #ProudReal patients. Real results. ​

Patient feedback is at the heart of what we do. We are proud to care for each and every person who walks through our doors. Thank you to everyone who has shared their experience with Skin Medical.​

Visit our website to discover more. Link in bio. 🔗

#SkinMedical #aestheticmedicine #patientfeedbackA subtle refresh for the under-eye area. 

Tear trough treatment can help reduce the appearance of tiredness, restoring a brighter, more rested look while keeping results natural.

This result was achieved by using @revanesseukofficial Revise filler. The treatment performed by @dr.saifabbas at SkinMedical.

Visit our website to discover more. Link in Bio.

*Actual patient, individual results may vary.

#aesthetictreatments #teartroughfillers #SkinMedical

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